According to the Global Dendritic Cell Cancer Vaccine Market Dosage Price & Clinical Trials Outlook 2024 report, more than 60 dendritic cell vaccines are currently undergoing trials.
This is one of the most promising cancer immunotherapy areas, although most drugs are still unapproved and considered experimental.
Unfortunately, oncological diseases progress pretty rapidly, especially in the advanced stages. Most people with cancer don’t have a few years to wait until research is complete and vaccines are included in treatment protocols.
If you want a dendritic cell vaccine soon, you can undergo dendritic cell cancer therapy in Germany. Some specialized centers already use dendritic cell vaccines in clinical practice with good results.
What Is the Use of Dendritic Cells in Cancer Treatment?
Dendritic cells (DCs) are a type of immune cell whose task is to present antigen to T-cells. DCs capture a large protein molecule, divide it into parts, and present it to other immune cells, which, receiving this information, learn to recognize a foreign cell, such as a bacterial or tumor cell.
As a result, T-cells attack the foreign agent. Without the help of DCs, they would not be able to recognize it, and an adequate immune response would not develop.
In cancer, the DC activity is reduced. This is one of the mechanisms that cancer cells use to defend themselves against the immune system. As a result, T-cells have a weak response to the tumor, and there is no normal anticancer immunity.
But it can be boosted. A DC-based cancer vaccine is used to stimulate the immune system. As a result of administering such a vaccine, T-cells receive information about tumor antigens, attack these targets, and destroy cancer cells.
With an excellent response to therapy, the primary tumor and its metastases shrink in size already in the first weeks after the drug is administered.
Where to Buy German Dendritic Cell Cancer Vaccine？
You cannot buy a https://www.nature.com/articles/d41586-024-00841-ycancer vaccine from the nearest pharmacy. It needs to be manufactured individually for each patient, using their own DCs and possibly even tumor fragments.
Dendritic cell therapy in Germany is conducted as follows:
- Monocytes are isolated from your blood
- The monocytes are cultured to produce DCs
- In the laboratory, DCs are matured, and tumor antigens are added
- Trained mature DCs are injected subcutaneously
- DCs migrate to lymph nodes, meet T-lymphocytes, and transmit information about tumor antigens to them
- A cellular immune response is triggered, with T-lymphocytes attacking cancer cells throughout the body
- The tumor mass rapidly shrinks
DCs-based vaccines are often supplemented with other immunotherapies to enhance the effect by combining them with immune checkpoint inhibitors or oncolytic viruses.
Who Is a Candidate for the Cancer Vaccine?
So far, there are only two cancer vaccines that are part of cancer treatment protocols: those for prostate cancer and melanoma. But dozens of other types of cancer can also be treated with DCs, so far in clinical trials.
There are already vaccines against glioblastoma (brain cancer), pleural mesothelioma, osteosarcoma, breast, lung, colon, kidney, pancreatic cancer, and many other pathologies.
If you want to know if a vaccine is available to treat your disease, leave a request on the Booking Health website. We will advise you on possible treatments abroad and help you find a clinic where DCs are used.
Most often, dendritic cell vaccines and other types of immunotherapy are used at stage 4 of the disease. Another area of their application is adjuvant cancer therapy: DCs can be included in the drug treatment regimen after surgery to reduce the risk of recurrence.
Advantages of Cancer Vaccines
The main advantage of cancer treatment with dendritic cell vaccine is the absence of significant toxicity. Unlike chemotherapeutic agents, DCs do not have cytotoxic properties.
They do not damage cells but only enhance the antitumor immune response. Therefore, the leading side effects are flu-like symptoms that may persist for several days after vaccine administration.
Other advantages of DCs are:
- Compatibility with any other methods of cancer treatment
- Minimal contraindications
- Quick treatment without lengthy hospitalization (although vaccine production may take 2-3 weeks, the patient is not involved in the process and does not have to stay in the hospital)
- High efficacy at any stage of cancer, even the advanced stage
- DCs target not only the primary tumor but also all metastases
Check the therapy price and make an appointment for treatment on convenient dates via the Booking Health website. We will find a clinic for you whose doctors use dendritic cells to treat oncological diseases and organize your trip.
The cost of medical services when making an appointment through our service will be lower for you than when directly applying to the clinic due to the absence of additional charges for foreign patients.